Chemotherapy was potentiated by E7449 and single agent had major antitumor activity in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, most likely via TNKS inhibition. Per this likelihood, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and appreciably altered expression of Wnt focus on https://guyi307afj2.blogolenta.com/profile