If a dad or mum in the proband is understood to hold the pathogenic variant discovered from the proband, the risk to your sibs of inheriting the pathogenic variant is 50%. On account of reduced penetrance, sibs who inherit the pathogenic variant may or may not establish aHUS (see Penetrance). https://waterchillers10753.timeblog.net/68566300/helping-the-others-realize-the-advantages-of-ahu-s