Mutations in the gene coding for superoxide dismutase 1 (SOD1) are associated with familiar forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). These mutations are believed to result in a "gain of toxic function". leading to neuronal degeneration. The exact mechanism is still unknown. https://www.markbroyard.com/great-choice-fruit-cocktail-tree-for-sale-super-choice/