Exploration into conolidine has led to discovery of the opioid receptor in the body named ACKR3/CXCR7. ACKR3 seems to be the most desired target for conolidine, which also disregards the opposite four classical opioid receptors(three). thank you.. A: There is limited details on contraindications amongst Conolidine and blood thinners https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers